Located in Baltimore, Maryland is now a museum. Poe lived there from 1832 to 1835 with his Grandmother, aunt and his cousin (whom he later married). His Grandmother died there in 1835. The house changed hands many times during the next hundred years, and it remained empty from 1922 to 1949. After the house was turned into a museum, visitors began reporting strange goings-on.
Here are a couple of internet links about the house:
http://www.ci.baltimore.md.us/government/historic/poehouse.php
http://www.eapoe.org/balt/poehse.htm
Wouldn't this be a great place to investigate?